Research
- Link to my current CV (January 2025)
- Link to my publications on NCBI
- Link to my dissertation on Texas ScholarWorks
Single Cell Epigenomics at the Gene Regulation Observatory
The IGVF marker paper is out - read it here. If Nature is paywalled for you, the preprint on Pubmed is available here.Protocols.io links to the SHARE-seq v2 protocol, and our single cell genomics nuclei prep protocol below.
Functional Genomics: Cardiovascular Genetics
In the Ellinor laboratory, I worked on a variety of projects, many of which are now being published! Many of these projects also have results viewable at the Cardiovascular Disease knowledge portal. A selection of publications in which I've been involved include:- The impact of common and rare genetic variants on bradyarrhythmia development
- Transcriptional profile of the rat cardiovascular system at single-cell resolution
- Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias
- Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias
- Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass.
- Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
- Monogenic and Polygenic Contributions to QTc Prolongation in the Population
- Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels
- Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
- Deep learning enables genetic analysis of the human thoracic aorta
- Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis
- Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation
- Genetic Determinants of Electrocardiographic P-wave Duration and Relation to Atrial Fibrillation
- Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction
- Transcriptional and Cellular Diversity of the Human Heart
Functional Genomics: Glioblastoma multiforme
In the Iyer lab, I worked on several projects that relate to the genomics of glioblastoma multiforme (GBM).The culmination of my work there was to profile histone PTMs and RNA-seq in several primary GBM lesions. I also did collaborations with cardiologists at St. David's Hospital, and with Dr. Richard Aldrich (with whom I did a 3 year stint as a laboratory technician).
- Enhancers and bivalent regions clustered based on molecular subtype
- allele specific bias in ChIP-seq
- eQTL analysis of the GBM genome
- Selective genotyping of individuals undergoing cardiac ablation for atrial fibrillation
- Amino acid conservation across many phyla for the highly conserved calcium signaling protein calmodulin